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Orlistat Reviews

Drug Class and Mechanism


Orlistat helps in weight reduction by preventing fat absorption and digestion in the food consumed. Lipase is an enzyme produced by the pancreas that breaks down the fat and helps in its absorption. Orlistat reverses the action of lipase by preventing fat absorption and breakup. It blocks the absorption of 25% of the fat in a meal. The fat that is unabsorbed is expelled through stools.

Prescription, Storage and Dosage


Orlistat is prescribed for patients who are obese with a body mass index between 27 and 30 kg/m2. It works best when accompanied with a low-calorie and low-fat diet. It is also used to maintain weight after it has been lost. It is available as a prescription drug. However it comes under the brand names, Xenical and Alli. The latter is available as an over the counter medicine. There is no generic available and capsules should be stored at room temperature. The dosage for Xenical is a single capsule thrice a day. Alli needs to be taken in doses of 60 mg thrice a day. Orlistat needs to be taken one hour after or during food. Fat free meals do not require orlistat.

Drug Interactions


Warfarin produces a blood thinning effect that in turn depends on Vitamin K in the body. This is a vitamin that binds itself to fat. Therefore patients receiving warfarin who begin orlistat dosage should keep a tab on blood clotting as orlistat may reduce amounts of Vitamin K in the body. This can in turn cause abnormal bleeding by warfarin. Orlistat also reduces the absorption of cyclosporine when taken together. Hence cyclosporine should be taken two hours prior or after orlistat. Reports have shown that when orlistat is combined with levothyroxine cases of hypothyroidism are seen. When both these are taken together thyroid function should be monitored. Also these should be taken after an interval of four hours.

Orlistat Side Effects


Common side effects include oily spotting on underwear, urgency in passing bowels, frequent stools, pain in the abdomen and flatulence. Side effects are very common in the first three months of treatment. Consuming meals that are not more than 30% in their quantity of fat can reduce them. This is because unabsorbed fat causes majority of these symptoms. Patients with a history of kidney stones should be careful as this drug may increase the risk of kidney stones. Liver failure has also been reported in patients taking this medicine. Also dietary vitamins stick to fat and may get eliminated with the fat. Therefore it is advisable to consume multi-vitamins so as to prevent the risk of vitamin deficiencies. These should be taken 2 hours before or many hours after the dosage of orlistat.

2 yorum:

Sally said...

It is a really good article

Losing Weight said...

Losing Weight...

You have brought up a very good points , regards for the post....

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