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Phentermine Reviews

Drug Class and Mechanism


Phentermine is an appetite reducer. The exact mechanism of this drug is unknown but it is believed that this drug decreases appetite by working on that area of the brain, which regulates appetite and hunger. It also increases blood pressure and heart rate and at the same time stimulates the nervous system. Generics of this drug are available.

Prescription, Storage and Dosage


It is a prescription drug and it is not available as an over the counter drug. It comes under the brand names; Adipex-P, Oby-Trim and Obenix. This drug comes in the form of tablets of 30 and 37.5mg. Phentermine should be stored in an airtight container and at room temperature only. It is recommended for the treatment of obesity and when combined with diet and exercise it is known to be effective. It is apt for people with a body mass index that is greater than 30kg/m2. However this drug should not be combined with other agents that help weight loss. The maximum dosage is 30mg once per day, preferably 2 hours after breakfast. Evening doses should be avoided as these keep the body very active causing insomnia.

Drug Interactions


Phentermine when combined with tricyclic antidepressants causes high blood pressure. It is similar to amphetamine. It can cause serious reactions when combined with monoamine oxidase inhibitors by elevating the levels of serotonin in the blood.

Phentermine Side Effects


The most common side effects of phentermine include nausea with vomiting, diarrhea and constipation. Cases of developing a dry mouth and an unpleasant taste are also noted side effects. Certain other serious side effects include impotency, heart palpitations and high levels of blood pressure. Side effects related to the central nervous system include insomnia, tremors, restlessness, giddiness and also hyperactivity. When combined with a drug called fenfluramine serious complications are seen. Some of these include high pressure in the pulmonary arteries. Defects in the heart valves are also seen which is also a serious side effect. The constant and long-term use of phentermine can cause not just physical and psychological dependence. Withdrawal symptoms include fatigue, depression and tremors. The use of phentermine in pregnant women has not been evaluated adequately. There is no study to show the presence of phentermine in human breast milk.

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